Cresset BMD FieldTemplater 2.1.1, Cresset has pioneered an innovative approach to 3D computational drug discovery. Our molecular fields provide an accurate representation of molecules which is more closely aligned to the protein's viewpoint than the traditional atom and bonds ("bare bones") approach. These fields summarise key binding features and explain how active compounds with quite different structures can make similar interactions with a protein active site. Fields free chemists from the constraints of structure-based thinking, so they can discover new chemistry directions.
We have created software allowing chemists and modellers to apply field technology to hit-finding, lead-switching, molecular alignment and determination of bound conformations. The software is available for annual lease or purchase.
Cresset also offers a cost-effective hit-finding and lead-optimisation support service, allowing you to find compounds with unprecedented structural diversity that are ideal starting points for medicinal chemistry programs.FieldFocus™ libraries: Cresset is collaborating with BioFocus DPI to produce focused libraries for hit-finding. These are designed using Cresset's field technology and synthesized by BioFocus DPI's experienced library chemists.